![]() Combination of finite element 397 method and drucker-prager cap material model for simulation of pharma398 ceutical tableting process: Kombination der finite-elemente-methode mit dem drucker-prager cap materialmodel zur simulation von pharmazeutis400 chen tablettierungsprozessen. ISSN 17447593.īaroutaji A, Lenihan S, Bryan K. Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups. AIP Conference Proceedings vol 20005 2020.Īleksovski A, Dreu R, Gǎperlin M, Planiňek O. Mathematical models for stress-strain curve prediction-a. ![]() Powder Technol 1996 88(2):155–163.Īhmad J, Noor MJM, Jais MIF, Rahman ASA, Senin SF, Ibrahim A, Hadi BA. Micromechanical analyses of the pressure-volume relationship for powders under confined uniaxial compression. Abaqus theory manual version 6.6-1: Abaqus.Īdams MJ, McKeown R. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Ībaqus I. ![]() Furthermore, it is observed that bevel-edged tablets could facilitate the formation of cracks, leading to possible capping failure.ĭensity distribution finite element modeling mini-tablets powder compaction stress distribution. The model predictions in terms of stress and density distribution at different stages of the compaction process indicate similar behavior in terms of density and stress distribution profiles between the conventionally sized tablets and mini-tablets for a particular excipient.īased on tablet size, small localized differences are noted (e.g., low-density regions, high shear bands, and heterogeneous density profiles), suggesting a possible risk of tableting defects for conventionally sized tablets compared to mini-tablets. Each tablet size is simulated using four distinctive excipients, Avicel ® PH-102, Kollidon ® VA64, Pearlitol ® 100SD, and Supertab ® 11SD, and two different punch geometries, a flat-face punch, and a bevel edge punch. The numerical simulation cases consist of four different die sizes, mini-tablets of 2 mm, and 3 mm, and conventionally sized tablets of 8 mm and 11.28 mm. In this paper, the influence of powder properties and process parameters, such as punch shape and size, on the evolution of mechanical properties during the tableting process and the potential occurrence of tablet defects are investigated using the mechanistic modeling approach, Finite Element Method (FEM). Nevertheless, only a few experimental studies are available in the literature regarding this topic and technical aspects, such as punch's shape and size effect on the stress and density distribution in the compact mini-tablets, are still not fully investigated. Mini-tablets are considered a promising solid dosage form in the pharmaceutical industry due to advantages such as dosing accuracy, efficiency as a drug delivery system, and alleged improvement in mechanical properties.
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